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26 September 2013

The teenage hormone that triggers puberty and prevents cancer

The appropriately named kisspeptin was discovered by accident, and has some surprising effects.

By Michael Brooks

Whatever your parents told you, it’s not about the birds and the bees. Ultimately, reproduction seems to be about a protein molecule called kisspeptin. The name has nothing to do with foreplay, however. Kisspeptin was discovered in Hershey, Pennsylvania, and its name comes from the town’s other great research success: Hershey’s Kisses chocolates.

At some point, most people’s brain starts to secrete kisspeptin; when it does, the hypothalamus begins to produce a chemical called gonadotropin-releasing hormone, or GnRH. Written down, it looks like a teenage grunt and that’s what it leads to. GnRH release is a crucial moment at the beginning of puberty. It brings about the secretion of hormones that start egg or sperm production and create the characteristic signs of sexual maturity.

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